Description
Manufacturer:
Sun Pharmaceutical Industries Ltd.
Salt Composition:
Sodium Valproate IP 200 mg + Valproic Acid IP 87 mg (Equivalent to Valproate 300 mg)
Description:
Encorate Chrono 300 Tablet CR is a combination medication formulated for the management of epilepsy and bipolar disorder. It contains a mixture of sodium valproate and valproic acid, which together provide a total valproate equivalent of 300 mg. The “Chrono” designation and “CR” abbreviation indicate that this is a controlled-release formulation. This means the medication is released slowly and steadily into the bloodstream over an extended period, which helps to maintain a more consistent therapeutic level, reduce the frequency of dosing, and potentially minimize some side effects associated with rapid fluctuations in drug concentration.
Valproate is a broad-spectrum antiepileptic drug that works through multiple mechanisms in the brain. It is believed to increase the levels of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter that helps to calm overactive nerve activity in the brain, which is often implicated in seizures. Additionally, it may affect sodium and calcium channels, further stabilizing neuronal excitability. As an antiepileptic, Encorate Chrono 300 Tablet CR is effective in controlling various types of seizures, including absence seizures, generalized tonic-clonic seizures, and partial seizures.
Beyond epilepsy, valproate is also a mood stabilizer used in the treatment of bipolar disorder, particularly for managing manic episodes. It helps to stabilize mood swings, reducing the intensity and frequency of manic episodes and can also be used for maintenance therapy to prevent future episodes of mania, depression, or mixed states associated with bipolar disorder. The precise mechanisms by which valproate exerts its mood-stabilizing effects are not fully understood but are thought to involve its influence on neurotransmitter systems in the brain.
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